Cell and Molecular Biology of the TestisClaude Desjardins, Larry L. Ewing This book is a comprehensive, multi-authored work on the structure and function of the mammalian testis. The approach emphasizes gene expression, translation and production of specific gene products and the cellular and molecular regulation of these fundamental processes. Rather than provide a global survey of all aspects of male reproduction, this book stresses specific mechanisms that underscore the structure and function of the testis. It explains old and new concepts from a cellular and molecular perspective. This novel approach allows the authors to forge links between cell and molecular biology and well-established aspects of spermatogenesis and steroidogenesis. The result is a well-focused, comprehensive, and synthetic analysis of testicular biology. |
Contents
Cell Biology of Testicular Development in the Fetus and Neonate | 3 |
Molecular Genetics of the Human and Mouse YChromosome | 43 |
Development of the Germ Cell | 58 |
Genetic Control of Spermatogenesis and Steroidogenesis | 90 |
Mullerian Inhibiting Substance | 108 |
Design and Function of the Microcirculation | 127 |
Structure and Function | 145 |
Gonadotropins and Androgens | 166 |
Spermatogonial Stem Cells | 266 |
The Process of Meiosis | 296 |
Cell Biology of Mammalian Spermiogenesis | 332 |
Cellular Interactions in the Seminiferous Epithelium | 377 |
Gene Expression During Male Germ Cell Development | 400 |
Patterns of Expression and Potential Functions of Cellular Oncogenes and Heat Shock | 433 |
Expression and Localization in the Testis | 452 |
Regulation of Testicular Autoimmune Disease | 474 |
Common terms and phrases
Acad acrosome activin activity adult rat Anat androgen antibodies antigen Bardin binding Biochem Biol bovine cDNA cell types cellular cholesterol chromosome Clermont clone compartment culture cycle cytoplasm days pc differentiation Donahoe effect embryo encoding Endocrinol Endocrinology enzyme epididymal fetal fluid function gene mutations genetic genome germ cell line gonads gonocytes growth factor H-Y antigen hormone human implants inhibin interactions interstitial levels Leydig cells male germ mammalian meiosis meiotic mice mitochondrial molecular molecules mouse mRNA myoid cells normal oocytes pachytene peptides percent peritubular PGCs plasma membrane primordial germ cells production proliferation protein rat testis receptor region regulation Reprod role secretion seminiferous epithelium seminiferous tubule sequences Sertoli cells serum somatic specific sper sperm spermatids spermato spermatocytes spermatogenesis spermatogenic spermatogonia spermatozoa stages stem cells steroid steroidogenesis steroidogenic stimulation studies surface synthesis testes testicular testosterone tion tissue transcription vitro vivo Y chromosome
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